Real-time monitoring of biofilm growth identifies andrographolide as a potent antifungal compound eradicating Candida biofilms.

ABSTRACT: Candida species cause life-threatening infections with high morbidity and mortality rates and their resistance to conventional therapy is closely linked to biofilm formation. Thus, the development of new approaches to study Candida biofilms and the identification of novel therapeutic strategies could yield improved clinical outcomes. In the current study, we have set up an impedance-based in vitro system to study Candida spp. biofilms in real-time and to evaluate their sensitivity to two conventional antifungal groups used in clinical practice - azoles and echinocandins. Both fluconazole and voriconazole were unable to inhibit biofilm formation in most strains tested, while echinocandins showed biofilm inhibitory capacity at relatively low concentrations

SUBMITTER: Ziemyte M 

PROVIDER: S-EPMC10313501 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature