Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes: an exploratory study.

ABSTRACT:

Background

Children born very preterm (VPT; <32 weeks' gestation) are at high risk of neurodevelopmental and behavioural difficulties associated with atypical brain maturation, including socio-emotional difficulties. The analysis of large-scale brain network dynamics during rest allows us to investigate brain functional connectivity and its association with behavioural outcomes.

Methods

Dynamic functional connectivity was extracted by using the innovation-driven co-activation patterns framework in VPT and full-term children aged 6-9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity (VPT, n = 28; full-term, n = 12). Multivariate analysis was used to explore potential biomarkers for socio-emotional difficulti

SUBMITTER: Siffredi V 

PROVIDER: S-EPMC10313511 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature