Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas.

ABSTRACT: Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine mammary tumours (CMTs) such as simple canine mammary carcinomas represent valuable models for human breast cancer also with respect to stromal reprogramming. However, it remains unclear whether and how CAS changes in metastatic tumours compared to non-metastatic ones. To characterize stromal changes between metastatic and non-metastatic CMTs and identify potential drivers of tumour progression, we analysed CAS and matched normal stroma from 16 non-metastatic and 15 metastatic CMTs by RNA-sequencing of microdissected FFPE tissue. We identified 1438 differentially regulated genes between CAS and normal stroma, supporting previous results demonstra

SUBMITTER: Ettlin J 

PROVIDER: S-EPMC10313573 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature