Nuclear transport maintenance of USP22-AR by Importin-7 promotes breast cancer progression.

ABSTRACT: The translocation of biological macromolecules between cytoplasm and nucleus is of great significance to maintain various life processes in both normal and cancer cells. Disturbance of transport function likely leads to an unbalanced state between tumor suppressors and tumor-promoting factors. In this study, based on the unbiased analysis of protein expression differences with a mass spectrometer between human breast malignant tumors and benign hyperplastic tissues, we identified that Importin-7, a nuclear transport factor, is highly expressed in breast cancer (BC) and predicts poor outcomes. Further studies showed that Importin-7 promotes cell cycle progression and proliferation. Mechanistically, through co-immunoprecipitation, immunofluorescence, and nuclear-cytoplasmic protein separatio

SUBMITTER: Cai GX 

PROVIDER: S-EPMC10313651 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature