Exploratory genome-wide analyses of cortical inhibition, facilitation, and plasticity in late-life depression.

ABSTRACT: Late-life depression (LLD) is a heterogenous mood disorder influenced by genetic factors. Cortical physiological processes such as cortical inhibition, facilitation, and plasticity may be markers of illness that are more strongly associated with genetic factors than the clinical phenotype. Thus, exploring the relationship between genetic factors and these physiological processes may help to characterize the biological mechanisms underlying LLD and improve diagnosis and treatment selection. Transcranial magnetic stimulation (TMS) combined with electromyography was used to measure short interval intracortical inhibition (SICI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS) in 79 participants with LLD. We used exploratory genome-wide

SUBMITTER: Wathra RA 

PROVIDER: S-EPMC10313655 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature