Ontology highlight
ABSTRACT:
SUBMITTER: Danielsson BE
PROVIDER: S-EPMC10313699 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Danielsson Brooke E BE George Abraham Bobin B Mäntylä Elina E Cabe Jolene I JI Mayer Carl R CR Rekonen Anna A Ek Frans F Conway Daniel E DE Ihalainen Teemu O TO
Nature communications 20230630 1
Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA. However, to date there is not yet a technical approach to directly measure mechanical forces on nuclear lamins at the protein level. To overcome this limitation, we developed a nanobody-based intermolecular tension FRET biosensor capable of measuring the mechanical strain of lamin fila ...[more]