Multinuclear 1D and 2D NMR with ¹⁹F-Photo-CIDNP hyperpolarization in a microfluidic chip with untuned microcoil.

ABSTRACT: Nuclear Magnetic Resonance (NMR) spectroscopy is a most powerful molecular characterization and quantification technique, yet two major persistent factors limit its more wide-spread applications: poor sensitivity, and intricate complex and expensive hardware required for sophisticated experiments. Here we show NMR with a single planar-spiral microcoil in an untuned circuit with hyperpolarization option and capability to execute complex experiments addressing simultaneously up to three different nuclides. A microfluidic NMR-chip in which the 25 nL detection volume can be efficiently illuminated with laser-diode light enhances the sensitivity by orders of magnitude via photochemically induced dynamic nuclear polarization (photo-CIDNP), allowing rapid detection of samples in the lower picomol

SUBMITTER: Gomez MV 

PROVIDER: S-EPMC10313780 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature