Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery.

ABSTRACT:

Introduction

Mesenchymal stem cells (MSCs) are novel, promising agents for treating ocular surface disorders. MSCs can be isolated from several tissues and delivered by local or systemic routes. They produce several trophic factors and cytokines, which affect immunomodulatory, transdifferentiating, angiogenic, and pro-survival pathways in their local microenvironment via paracrine secretion. Moreover, they exert their therapeutic effect through a contact-dependent manner.

Areas covered

In this review, we discuss the characteristics, sources, delivery methods, and applications of MSCs in ocular surface disorders. We also explore the potential application of MSCs to inhibit senescence at the ocular surface.

Expert opinion

Therapeutic application of MSCs in ocular surfac

SUBMITTER: Soleimani M 

PROVIDER: S-EPMC10313829 | biostudies-literature | 2023 Jan-Jun

REPOSITORIES: biostudies-literature