Simulation study for evaluating an adaptive-randomisation Bayesian hybrid trial design with enrichment.

ABSTRACT:

Background

As we enter the era of precision medicine, the role of adaptive designs, such as response-adaptive randomisation or enrichment designs in drug discovery and development, has become increasingly important to identify the treatment given to a patient based on one or more biomarkers. Tailoring the ventilation supply technique according to the responsiveness of patients to positive end-expiratory pressure is a suitable setting for such a design.

Methods

In the setting of marker-strategy design, we propose a Bayesian response-adaptive randomisation with enrichment design based on group sequential analyses. This design combines the elements of enrichment design and response-adaptive randomisation. Concerning the enrichment strategy, Bayesian treatment-by-subset interact

SUBMITTER: Vinnat V 

PROVIDER: S-EPMC10313856 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature