Unilateral caudate inactivation increases motor impulsivity in rhesus monkeys.

ABSTRACT: Impulsivity, the tendency to react quickly and without consideration of consequences, is correlated with asymmetry in the volume of the caudate nucleus in human patients. In this study, we sought to determine whether the induction of functional asymmetry in the caudate nucleus of monkeys would produce phenomenologically comparable behavior. We found that unilateral suppression of the ventral caudate nucleus increases impulsive behavior in rhesus monkeys. Impulsivity was modeled by the subjects' inability to maintain hold of a touch-sensitive bar until presentation of an imperative signal. Two methods were used to suppress activity in the caudate region. First, muscimol was locally infused. Second, a viral construct expressing the hM₄Di DREADD (designer receptor exclusively activ

SUBMITTER: Eldridge MAG 

PROVIDER: S-EPMC10313876 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature