Disease-associated metabolic pathways affected by heavy metals and metalloid.

ABSTRACT: Increased exposure to environmental heavy metals and metalloids and their associated toxicities has become a major threat to human health. Hence, the association of these metals and metalloids with chronic, age-related metabolic disorders has gained much interest. The underlying molecular mechanisms that mediate these effects are often complex and incompletely understood. In this review, we summarize the currently known disease-associated metabolic and signaling pathways that are altered following different heavy metals and metalloids exposure, alongside a brief summary of the mechanisms of their impacts. The main focus of this study is to explore how these affected pathways are associated with chronic multifactorial diseases including diabetes, cardiovascular diseases, cancer, neurodegene

SUBMITTER: Haidar Z 

PROVIDER: S-EPMC10313886 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature