Distinct immune microenvironment of lung adenocarcinoma in never-smokers from smokers.

ABSTRACT: Lung cancer in never-smokers (LCINS) presents clinicopathological and molecular features distinct from that in smokers. Tumor microenvironment (TME) plays important roles in cancer progression and therapeutic response. To decipher the difference in TME between never-smoker and smoker lung cancers, we conduct single-cell RNA sequencing on 165,753 cells from 22 treatment-naive lung adenocarcinoma (LUAD) patients. We find that the dysfunction of alveolar cells induced by cigarette smoking contributes more to the aggressiveness of smoker LUADs, while the immunosuppressive microenvironment exerts more effects on never-smoker LUADs' aggressiveness. Moreover, the SPP1^hi pro macrophage is identified to be another independent source of monocyte-derived macrophage. Importantly, higher exp

SUBMITTER: Luo W 

PROVIDER: S-EPMC10313938 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature