Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

ABSTRACT:

Objectives

The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap.

Methods

Genome-wide data from 8467 patients with any of the main forms of vasculitis and 29 795 healthy controls were meta-analysed using ASSET. Pleiotropic variants were functionally annotated and linked to their target genes. Prioritised genes were queried in DrugBank to identify potentially repositionable drugs for the treatment of vasculitis.

Results

Sixteen variants were independently associated with two or

SUBMITTER: Ortiz-Fernandez L 

PROVIDER: S-EPMC10314028 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature