Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

ABSTRACT:

Objectives

Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been associated with hand OA but none with EHOA.

Methods

We performed meta-analysis of EHOA in 1484 cases and 550 680 controls, from 5 populations. To identify causal genes, we performed eQTL and plasma pQTL analyses, and developed one zebrafish mutant. We analysed associations of variants with other traits and estimated shared genetics between EHOA and other traits.

Results

Four common sequence variants associated with EHOA, all with relatively high effect. Rs17013495 (SPP1/MEPE, OR=1.40, p=8.4×10^-14) and rs11243284 (6p24.3, OR=1.35, p=4.2×10

SUBMITTER: Styrkarsdottir U 

PROVIDER: S-EPMC10314032 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature