FOXO3A acts as immune response modulator in human virus-negative inflammatory cardiomyopathy.

ABSTRACT:

Objective

Inflammatory cardiomyopathy is characterised by inflammatory infiltrates leading to cardiac injury, left ventricular (LV) dilatation and reduced LV ejection fraction (LVEF). Several viral pathogens and autoimmune phenomena may cause cardiac inflammation.The effects of the gain of function FOXO3A single-nucleotide polymorphism (SNP) rs12212067 on inflammation and outcome were studied in a cohort of patients with inflammatory dilated cardiomyopathy (DCMi) in relation to cardiac viral presence.

Methods

Distribution of the SNP was determined in virus-positive and virus-negative DCMi patients and in control subjects without myocardial pathology. Baseline and outcome data were compared in 221 virus-negative patients with detection of cardiac inflammation and reduc

SUBMITTER: Makrutzki-Zlotek K 

PROVIDER: S-EPMC10314059 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature