Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases.

ABSTRACT:

Objective

The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway.

Design

Targeted quantitative metabolomics was performed in two large human IBD cohorts (1069 patients with IBD). Dextran sodium sulphate-induced colitis experiments in mice were used to evaluate effects of identified metabolites. In vitro, ex vivo and in vivo experiments were used to decipher mechanisms involved. Effects on energy metabolism were evaluated by different methods including Single Cell mEtabolism by profiling Translation inHibition.

Results

SUBMITTER: Michaudel C 

PROVIDER: S-EPMC10314090 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature