Bifidobacterium promotes retinal ganglion cell survival by regulating the balance of retinal glial cells.

ABSTRACT:

Introduction

Optic nerve injury is a leading cause of irreversible blindness worldwide. The retinal ganglion cells (RGCs) and their axons cannot be regenerated once damaged. Therefore, reducing RGC damage is crucial to prevent blindness. Accordingly, we aimed to investigate the potential influence of the gut microbiota on RGC survival, as well as the associated action mechanisms.

Methods

We evaluated the effects of microbiota, specifically Bifidobacterium, on RGC. Optic nerve crush (ONC) was used as a model of optic nerve injury. Vancomycin and Bifidobacterium were orally administered to specific pathogen-free (SPF) mice.

Results

Bifidobacterium promoted RGC survival and optic nerve regeneration. The administration of Bifidobacterium inhibited microglia activation but

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10314105 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature