Nuclear morphology predicts cell survival to cisplatin chemotherapy.

ABSTRACT: The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with treatment initially reducing overall tumor burden followed by resistant recurrent disease. While molecular mechanisms underlying resistance phenotypes have been explored, less is known about the cell biological characteristics of cancer cells that survive to eventually seed the recurrence. To identify the unique phenotypic characteristics associated with survival upon chemotherapy exposure, we characterized nuclear morphology and function as prostate cancer cells recovered following cisplatin treatment. Cells that survived in the days and weeks after treatment and resisted therapy-induced cell death showed increasing cell size and nuclear size, enabled by continuous endocycling resulting in repeated w

SUBMITTER: Kim CJ 

PROVIDER: S-EPMC10314150 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature