At-line porosity sensing for non-destructive disintegration testing in immediate release tablets.

ABSTRACT: Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commercial samples are studied. Multiple measurements on individual tablets quantify the random errors in the terahertz results. These show that the measurements of refractive index are precise, with the standard deviation on a single tablet being about 0.002, with variation between measurements being due to small errors in thickness measurement and from the resolution of the instrument. Six batches of 1000 tablets each were directly compressed using a rotary press. The tabletting turret speed (10 and 30 rpm) and compaction pressure (50, 100 and 200 

SUBMITTER: Bawuah P 

PROVIDER: S-EPMC10314216 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature