Identification of cuproptosis-related molecular subtypes as a biomarker for differentiating active from latent tuberculosis in children.

ABSTRACT:

Background

Cell death plays a crucial role in the progression of active tuberculosis (ATB) from latent infection (LTBI). Cuproptosis, a novel programmed cell death, has been reported to be associated with the pathology of various diseases. We aimed to identify cuproptosis-related molecular subtypes as biomarkers for distinguishing ATB from LTBI in pediatric patients.

Method

The expression profiles of cuproptosis regulators and immune characteristics in pediatric patients with ATB and LTBI were analyzed based on GSE39939 downloaded from the Gene Expression Omnibus. From the 52 ATB samples, we investigated the molecular subtypes based on differentially expressed cuproptosis-related genes (DE-CRGs) via consensus clustering and related immune cell infiltration. Subtype-specific

SUBMITTER: Chen L 

PROVIDER: S-EPMC10314436 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature