Association of statin use and increase in lipoprotein(a): a real-world database research.

ABSTRACT:

Background

There is an increased concern that statins may have an unintended effect of elevated lipoprotein(a) [Lp(a)]. We conducted a large sample real-world study to test the association.

Methods

This retrospective cohort study was conducted using data from an integrated SuValue database, which includes 221 hospitals across China covering more than 200,000 of population with longitudinal follow-up to 10 years. Propensity score matching was applied to identify two comparable cohorts with statin users and non-statin users. Detailed follow-up information such as Lp(a) levels were extracted. The hazard ratio was calculated on Lp(a) changes based on the statin usage cohorts. Detailed subgroup and different characteristic cohorts' analyses were also conducted.

Results

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SUBMITTER: Feng T 

PROVIDER: S-EPMC10314451 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature