Multicentre, randomised, double-blind, parallel controlled trial to investigate timing of platelet inhibition after coronary artery bypass grafting: TOP-CABG trial study.

ABSTRACT:

Introduction

Dual antiplatelet therapy (DAPT), referred to as the combination of aspirin and P2Y₁₂ receptor antagonist (clopidogrel or ticagrelor), potentially improves patency of saphenous vein grafts (SVG) after coronary artery bypass grafting (CABG), while it is further proposed that DAPT potentially increases bleeding risk. Compared with DAPT, de-escalated DAPT (De-DAPT) is an effective antiplatelet strategy for acute coronary syndrome treatment, which significantly reduces the risk of bleeding without increasing the incidence of major adverse cardiovascular events. However, insufficient evidence is available to determine the timing of DAPT after CABG.

Methods and analysis

ETHICS AND DISSEMINATION: The Ethics Committee in Fuwai hospital approved this study (20

SUBMITTER: Yuan X 

PROVIDER: S-EPMC10314523 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature