Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China.

ABSTRACT:

Introduction

Metabolomic signatures of type 2 diabetes mellitus (T2DM) in Tibetan Chinese population, a group with high diabetes burden, remain largely unclear. Identifying the serum metabolite profile of Tibetan T2DM (T-T2DM) individuals may provide novel insights into early T2DM diagnosis and intervention.

Methods

Hence, we conducted untargeted metabolomics analysis of plasma samples from a retrospective cohort study with 100 healthy controls and 100 T-T2DM patients by using liquid chromatography-mass spectrometry.

Results

The T-T2DM group had significant metabolic alterations that are distinct from known diabetes risk indicators, such as body mass index, fasting plasma glucose, and glycosylated hemoglobin levels. The optimal metabolite panels for predicting T-T2DM

SUBMITTER: Meng J 

PROVIDER: S-EPMC10314538 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature