The application of mechanical load onto mouse tendons by magnetic restraining represses Mmp-3 expression.

ABSTRACT:

Objectives

Mechanical loading is crucial for tendon matrix homeostasis. Under-stimulation of tendon tissue promotes matrix degradation and ultimately tendon failure. In this study, we examined the expression of tendon matrix molecules and matrix-degrading enzymes (matrix metalloproteinases) in stress-deprived tail tendons and compared to tendons that were mechanically loaded by a simple restraining method.

Data description

Isolated mouse tail fascicles were either floated or restrained by magnets in cell culture media for 24 h. The gene expression of tendon matrix molecules and matrix metalloproteinases in the tendon fascicles of mouse tails were examined by real-time RT-PCR. Stress deprivation of tail tendons increase Mmp3 mRNA levels. Restraining tendons represses these in

SUBMITTER: Mousavizadeh R 

PROVIDER: S-EPMC10314558 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature