Use of second-generation antipsychotics in autism spectrum disorder: a systematic review and meta-analysis protocol.

ABSTRACT:

Introduction

Atypical antipsychotics have been studied to treat autism spectrum disorder (ASD). However, like little is known about whether these drugs are effective and safe when compared in controlled and non-controlled settings. This study aims to assess the efficacy and safety of second-generation antipsychotics in ASD in randomised controlled trials (RCT) and observational studies.

Methods and analysis

This systematic review will include RCT and prospective cohorts evaluating second-generation antipsychotics in people 5 years and older diagnosed with ASD. Searches will be conducted in Medline, Embase, Cochrane Library, Epistemonikos, Lilacs, CINAHL, PsycINFO, trial registries and grey literature databases without restriction on publication status, year of publication an

SUBMITTER: Lopes LPN 

PROVIDER: S-EPMC10314573 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature