Dataset Information

Cardiac output and arteriovenous oxygen difference contribute to lower peak oxygen uptake in patients with fibromyalgia.

ABSTRACT:

Background

Patients with fibromyalgia (FM) exhibit low peak oxygen uptake ([Formula: see text]O_2peak). We aimed to detect the contribution of cardiac output to ([Formula: see text]) and arteriovenous oxygen difference [Formula: see text] to [Formula: see text] from rest to peak exercise in patients with FM.

Methods

Thirty-five women with FM, aged 23 to 65 years, and 23 healthy controls performed a step incremental cycle ergometer test until volitional fatigue. Alveolar gas exchange and pulmonary ventilation were measured breath-by-breath and adjusted for fat-free body mass (FFM) where appropriate. [Formula: see text] (impedance cardiography) was monitored. [Formula: see text] was calculated using Fick's equation. Linear regression slopes for oxygen cost (∆[Formula: see text]O₂/∆work rate) and [Formula: see text] to [Formula: see text]O₂ (∆[Formula: see text]/∆[Formula: see text]O₂) were calculated. Normally distributed data were reported as mean ± SD and non-normal data as median [interquartile range].

Results

[Formula: see text]O_2peak was lower in FM patients than in controls (22.2 ± 5.1 vs. 31.1 ± 7.9 mL∙min^-1∙kg^-1, P < 0.001; 35.7 ± 7.1 vs. 44.0 ± 8.6 mL∙min^-1∙kg FFM^-1, P < 0.001). [Formula: see text] and C(a-v)O₂ were similar between groups at submaximal work rates, but peak [Formula: see text] (14.17 [13.34-16.03] vs. 16.06 [15.24-16.99] L∙min^-1, P = 0.005) and C(a-v)O₂ (11.6 ± 2.7 vs. 13.3 ± 3.1 mL O₂∙100 mL blood^-1, P = 0.031) were lower in the FM group. No significant group differences emerged in ∆[Formula: see text]O₂/∆work rate (11.1 vs. 10.8 mL∙min^-1∙W^-1, P = 0.248) or ∆[Formula: see text]/∆[Formula: see text]O₂ (6.58 vs. 5.75, P = 0.122) slopes.

Conclusions

Both [Formula: see text] and C(a-v)O₂ contribute to lower [Formula: see text]O_2peak in FM. The exercise responses were normal and not suggestive of a muscle metabolism pathology.

Trial registration

ClinicalTrials.gov, NCT03300635. Registered 3 October 2017-Retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT03300635 .

SUBMITTER: Lehto T

PROVIDER: S-EPMC10314615 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Cardiac output and arteriovenous oxygen difference contribute to lower peak oxygen uptake in patients with fibromyalgia.

Lehto Taneli T Zetterman Teemu T Markkula Ritva R Arokoski Jari J Tikkanen Heikki H Kalso Eija E Peltonen Juha E JE

BMC musculoskeletal disorders 20230701 1

<h4>Background</h4>Patients with fibromyalgia (FM) exhibit low peak oxygen uptake ([Formula: see text]O<sub>2peak</sub>). We aimed to detect the contribution of cardiac output to ([Formula: see text]) and arteriovenous oxygen difference [Formula: see text] to [Formula: see text] from rest to peak exercise in patients with FM.<h4>Methods</h4>Thirty-five women with FM, aged 23 to 65 years, and 23 healthy controls performed a step incremental cycle ergometer test until volitional fatigue. Alveolar ...[more]

PMID: 37393269

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Project description:BackgroundExercise capacity is a strong predictor of survival in patients with coronary artery disease (CAD). Exercise capacity improves after cardiac rehabilitation exercise training, but previous studies have demonstrated a decline in peak oxygen uptake after ending a formal rehabilitation program. There is a lack of knowledge on how long-term exercise adherence can be achieved in CAD patients. We therefore assessed if a 12-month maintenance program following cardiac rehabilitation would lead to increased adherence to exercise and increased exercise capacity compared to usual care.Materials and methodsTwo-centre, open, parallel randomized controlled trial with 12 months follow-up comparing usual care to a maintenance program. The maintenance program consisted of one monthly supervised high intensity interval training session, a written exercise program and exercise diary, and a maximum exercise test every third month during follow-up. Forty-nine patients (15 women) on optimal medical treatment were included following discharge from cardiac rehabilitation. The primary endpoint was change in peak oxygen uptake at follow-up; secondary endpoints were physical activity level, quality of life and blood markers of cardiovascular risk.ResultsThere was no change in peak oxygen uptake from baseline to follow-up in either group (intervention group 27.9 (±4.7) to 28.8 (±5.6) mL·kg (-1) min (-1), control group 32.0 (±6.2) to 32.8 (±5.8) mL·kg (-1) min (-1), with no between-group difference, p = 0.22). Quality of life and blood biomarkers remained essentially unchanged, and both self-reported and measured physical activity levels were similar between groups after 12 months.ConclusionsA maintenance exercise program for 12 months did not improve adherence to exercise or peak oxygen uptake in CAD patients after discharge from cardiac rehabilitation compared to usual care. This suggests that infrequent supervised high intensity interval training sessions are inadequate to improve peak oxygen uptake in this patient group.Trial registrationClinicalTrials.gov NCT01246570.

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Dataset Information

Cardiac output and arteriovenous oxygen difference contribute to lower peak oxygen uptake in patients with fibromyalgia.

Background

Methods

Results

Conclusions

Trial registration

Publications

Cardiac output and arteriovenous oxygen difference contribute to lower peak oxygen uptake in patients with fibromyalgia.

Similar Datasets

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