Effects of metformin on bone mineral density and bone turnover markers: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Metformin is associated with osteoblastogenesis and osteoclastogenesis. This study aims to investigate the impacts of metformin therapy on bone mineral density (BMD) and bone turnover markers.

Design

Systematic review and meta-analysis of randomised controlled trials.

Methods

Searches were carried out in PubMed, EMBASE, Web of science, Cochrane library, ClinicalTrials.gov from database inception to 26 September 2022. Two review authors assessed trial eligibility in accordance with established inclusion criteria. The risk of bias was assessed using the Cochrane Risk of Bias tool (RoB V.2.0). Data analysis was conducted with Stata Statistical Software V.16.0 and Review Manager Software V.5.3.

Results

A total of 15 studies with 3394 participants were id

SUBMITTER: Hu J 

PROVIDER: S-EPMC10314630 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature