Identification of MiR-223 Associated with Diagnosis in Ectopic Pregnancy.

ABSTRACT:

Background

In this study, we conducted an integrated study of the diagnostic value of MiR-223 in ectopic pregnancy (EP).

Methods

We used GSE44731 downloaded from GEO and GEO2R to identify differentially expressed miRNA. The hub genes corresponding to the differential miRNA were then identified by using the Xiantao academic tool, GO (Gene Ontology), and KEGG (Kyoto Encyclopedia of Genes and Genomes). Afterward, we used the miEAA database to perform gene set enrichment analysis (GSEA) of differential miRNA, and used Xiantao academic tools again to conduct the ceRNA network based on the target genes. Protein-protein interaction (PPI) network construction and lncRNA of hub miRNA target genes were then predicted by the starbase database. For validation, the villus tissue from int

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10314770 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature