Contribution of TLR4 to colorectal tumor microenvironment, etiology and prognosis.

ABSTRACT:

Purpose

Toll-like receptor 4 (TLR4) is increasingly recognized for its ability to govern the etiology and prognostic outcomes of colorectal cancer (CRC) due to its profound immunomodulatory capacity. Despite widespread interest in TLR4 and CRC, no clear analysis of current literature and data exists. Therefore, translational advances have failed to move beyond conceptual ideas and suggestions.

Methods

We aimed to determine the relationship between TLR4 and CRC through a systematic review and analysis of published literature and datasets. Data were extracted from nine studies that reported survival, CRC staging and tumor progression data in relation to TLR4 expression. Primary and metastatic tumor samples with associated clinical data were identified through the Cancer Genome

SUBMITTER: Crame EE 

PROVIDER: S-EPMC10314848 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature