IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma.

ABSTRACT:

Purpose

Strategies for Indolamine-2,3-dioxygenase 1 (IDO1) inhibition in cancer immunotherapy once produced encouraging results, but failed in clinical trials. Recent evidence indicates that immune cells in the tumour microenvironment, especially macrophages, contribute to immune dysregulation and therefore might play a critical role in drug resistance.

Methods

In this study, we investigated the significance of IDO1 expressing immune cells in primary tumours and corresponding lymph node metastases (LNMs) in oral squamous cell carcinoma (OSCC) by immunohistochemistry. The link between IDO1 and macrophages was investigated by flow cytometry in tumour tissue, healthy adjacent tissue and peripheral blood mononuclear cells (PBMCs). IDO1 activity (measured as Kynurenine/Tryptophan

SUBMITTER: Struckmeier AK 

PROVIDER: S-EPMC10314853 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature