The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

Immune checkpoint inhibition is a therapeutic option in many cancer entities. In head and neck squamous cell carcinoma (HNSCC) targeting of the PD-1/PD-L1 (B7-H1) axis is approved in recurrent/metastatic disease and is being explored in the curative setting. Here, we evaluated two related members of the B7 family, B7-H3 & B7-H4, for their prognostic impact under standard treatment.

Methods

A tissue microarray (TMA) of a single center HNSCC cohort was stained for B7-H3 and B7-H4. Staining intensity and the number of tumor cells stained were assessed, and the expression was scored according to an established algorithm. Staining scores were correlated with clinicopathological parameters and associated with patient survival. mRNA levels of both proteins were associated w

SUBMITTER: Borgmann M 

PROVIDER: S-EPMC10314856 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature