Deciphering clinical significance of BCL11A isoforms and protein expression roles in triple-negative breast cancer subtype.

ABSTRACT:

Purpose

Triple negative breast cancer (TNBC) is an aggressive clinical tumor, accounting for about 25% of breast cancer (BC) related deaths. Chemotherapy is the only therapeutic option to treat TNBC, hence a detailed understanding of the biology and its categorization is required. To investigate the clinical relevance of BCL11A in TNBC subtype, we focused on gene and protein expression and its mutational status in a large cohort of this molecular subtype.

Methods

Gene expression profiling of BCL11A and its isoforms (BCL11A-XL, BCL11A-L and BCL11A-S) has been determined in Luminal A, Luminal B, HER2-enriched and TNBC subtypes. BCL11A protein expression has been analyzed by immunohistochemistry (IHC) and its mutational status by Sanger sequencing.

Results

In our study,

SUBMITTER: Angius A 

PROVIDER: S-EPMC10314865 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature