Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity.

ABSTRACT: Microgravity accelerates the aging of various physiological systems, and it is well acknowledged that aged individuals and astronauts both have increased susceptibility to infections and poor response to vaccination. Immunologically, dendritic cells (DCs) are the key players in linking innate and adaptive immune responses. Their distinct and optimized differentiation and maturation phases play a critical role in presenting antigens and mounting effective lymphocyte responses for long-term immunity. Despite their importance, no studies to date have effectively investigated the effects of microgravity on DCs in their native microenvironment, which is primarily located within tissues. Here, we address a significantly outstanding research gap by examining the effects of simulated microgravity

SUBMITTER: ElGindi M 

PROVIDER: S-EPMC10314949 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature