A promising cognitive screener in multiple sclerosis: The NIH toolbox cognition battery concords with gold standard neuropsychological measures.

ABSTRACT:

Background

Routine cognitive screening is a priority in MS clinical care. The National Institutes of Health Toolbox (NIHTB) Cognition Battery is a 30-min instrument validated in neurological populations excluding MS.

Objectives

To assess construct validity of NIHTB tests and compare classification of cognitive impairment with gold-standard tests. To evaluate relationships between fluid cognition and clinical measures.

Methods

Eighty-seven individuals, aged 30-59 years, completed the NIHTB, Minimal Assessment of Cognitive Function in MS (MACFIMS), Wechsler Adult Intelligence Scale-IV subtests, and measures of disease severity, depression, and fatigue.

Results

The NIHTB showed adequate convergent validity for processing speed, working memory, and episodic memory.

SUBMITTER: Manglani HR 

PROVIDER: S-EPMC10315105 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature