Mechanisms by which statins protect endothelial cells from radiation-induced injury in the carotid artery.

ABSTRACT:

Background

The incidental use of statins during radiation therapy has been associated with a reduced long-term risk of developing atherosclerotic cardiovascular disease. However, the mechanisms by which statins protect the vasculature from irradiation injury remain poorly understood.

Objectives

Identify the mechanisms by which the hydrophilic and lipophilic statins pravastatin and atorvastatin preserve endothelial function after irradiation.

Methods

Cultured human coronary and umbilical vein endothelial cells irradiated with 4 Gy and mice subjected to 12 Gy head-and-neck irradiation were pretreated with statins and tested for endothelial dysfunction, nitric oxide production, oxidative stress, and various mitochondrial phenotypes at 24 and 240 h after irradiation.

R

SUBMITTER: Ait-Aissa K 

PROVIDER: S-EPMC10315477 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature