Genomic landscape and expression profile of consensus molecular subtype four of colorectal cancer.

ABSTRACT:

Background

Compared to other subtypes, the CMS4 subtype is associated with lacking of effective treatments and poorer survival rates.

Methods

A total of 24 patients with CRC were included in this study. DNA and RNA sequencing were performed to acquire somatic mutations and gene expression, respectively. MATH was used to quantify intratumoral heterogeneity. PPI and survival analyses were performed to identify hub DEGs. Reactome and KEGG analyses were performed to analyze the pathways of mutated or DEGs. Single-sample gene set enrichment analysis and Xcell were used to categorize the infiltration of immune cells.

Results

The CMS4 patients had a poorer PFS than CMS2/3. CTNNB1 and CCNE1 were common mutated genes in the CMS4 subtype, which were enriched in Wn

SUBMITTER: Lu Y 

PROVIDER: S-EPMC10315486 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature