L-arginine-induced pancreatitis aggravated by inhibiting Na⁺/Ca²⁺ exchanger 1.

ABSTRACT: Na⁺/Ca²⁺ exchangers (NCX) are an exchange transporter of Na⁺ and Ca²⁺ ions on the plasma membrane. There are three types of NCX: NCX1, NCX2, and NCX3. We have been working for many years to understand the role of NCX1 and NCX2 in gastrointestinal motility. In this study, we focused on the pancreas, an organ closely related to the gastrointestinal tract, and used a mouse model of acute pancreatitis to investigate a possible role for NCX1 in the pathogenesis of pancreatitis. We characterized a model of acute pancreatitis induced by excessive doses of L-arginine. We administered the NCX1 inhibitor SEA0400 (1 mg/kg) 1 hr prior to L-arginine-induced pancreatitis and evaluated pathological changes. Mice treated with NCX1 inhibitors show exacerbation of

SUBMITTER: Ono N 

PROVIDER: S-EPMC10315542 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature