Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study.

ABSTRACT:

Background

The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear.

Objective

We aimed to investigate potential causal associations between age at menarche, age at natural menopause, and risk of lung and colorectal cancers using a Mendelian randomization (MR) approach.

Methods

From the Trøndelag Health Study in Norway, we defined two cohorts of 35 477 and 17 118 women to study the effects of age at menarche and age at natural menopause, respectively. We ran univariable MR to evaluate the potential causal associations. We performed multivariable MR adjusting for genetic variants of adult body mass index (BMI) to estimate the direct effect of age at menarche.

Results

Genetically predicted 1-year increase in age

SUBMITTER: Denos M 

PROVIDER: S-EPMC10315561 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature