Interplay of Cortisol, Testosterone, and Abdominal Fat Mass in Normal-weight Women With Polycystic Ovary Syndrome.

ABSTRACT:

Context

Ovarian and adrenal steroidogenesis underlie endocrine-metabolic dysfunction in polycystic ovary syndrome (PCOS). Adipocytes express aldo-keto reductase 1C3 and type 1 11β-hydroxysteroid dehydrogenase, which modulate peripheral androgen and cortisol production.

Objectives

To compare serum adrenal steroids, including 11-oxygenated androgens (11-oxyandrogens), cortisol, and cortisone between normal-weight women with PCOS and body mass index- and age-matched ovulatory women with normal-androgenic profiles (controls), and assess whether adrenal steroids associate with abdominal adipose deposition.

Design

Prospective, cross-sectional, cohort study.

Setting

Academic medical center.

Patients

Twenty normal-weight women with PCOS and 20 body mass index-/a

SUBMITTER: Dumesic DA 

PROVIDER: S-EPMC10315644 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature