Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study.

ABSTRACT:

Background

Metabolic disorders are a hallmark feature of cancer. However, the evidence for the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still lacking. We performed a two-sample Mendelian randomization (MR) analysis to assess the causality from genetically proxied 486 blood metabolites to CRC.

Methods

Genome-wide association study (GWAS) data for exposures were extracted from 7824 Europeans GWAS on metabolite levels. GWAS data for CRC from the GWAS catalog database GCST012879 were used for the preliminary analysis. The random inverse variance weighted (IVW) is the primary analysis for causality analysis while MR-Egger and weighted median as complementary analyses. Cochran Q test, MR-Egger intercept test, MR-PRESSO, Radial MR, and l

SUBMITTER: Yun Z 

PROVIDER: S-EPMC10315807 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature