Identification of potential drug targets for varicose veins: a Mendelian randomization analysis.

ABSTRACT:

Introduction

Varicose veins are a common chronic disease that creates a significant economic burden on the healthcare system. Current treatment options, including pharmacological treatments, are not always effective, and there is a need for more targeted therapies. A Mendelian randomization (MR) method uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, and it has been successful in identifying therapeutic targets in other diseases. However, few studies have used MR to explore potential protein drug targets for varicose veins.

Methods

To identify potential drug targets for varicose veins of lower extremities, we undertook a comprehensive screen of plasma protein with a two-sample MR method. We used recently reported

SUBMITTER: Lin J 

PROVIDER: S-EPMC10315832 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature