The effect of lung emptying before the inhalation of aerosol drugs on drug deposition in the respiratory system.

ABSTRACT: The amount of drug depositing in the airways depends, among others, on the inhalation manoeuvre and breathing parameters. The objective of this study was to quantify the effect of lung emptying before the inhalation of drugs on the lung doses. Thirty healthy adults were recruited. Their breathing profiles were recorded while inhaling through six different emptied DPI devices without breathe-out and after comfortable or forced exhalation. The corresponding emitted doses and aerosol size distributions were derived from the literature. The Stochastic Lung Model was used to estimate the deposited doses. In general, forceful exhalation caused increased flow rate and inhaled air volume. Increased flow rate led to the increase of the average lung dose for drugs with positive lung dose-flow rate c

SUBMITTER: Farkas A 

PROVIDER: S-EPMC10315997 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature