Pretargeted PET of Osteodestructive Lesions in Dogs.

ABSTRACT: The last decade has witnessed the creation of a highly effective approach to in vivo pretargeting based on the inverse electron demand Diels-Alder (IEDDA) click ligation between tetrazine (Tz) and trans-cyclooctene (TCO). Despite the steady progression of this technology toward the clinic, concerns have persisted regarding whether this in vivo chemistry will work in humans given their larger size and blood volume. In this work, we describe the use of a ⁶⁴Cu-labeled Tz radioligand ([⁶⁴Cu]Cu-SarAr-Tz) and a TCO-bearing bisphosphonate (TCO-BP) for the pretargeted positron emission tomography (PET) imaging of osteodestructive lesions in a large animal model: companion dogs. First, in a small animal pilot study, healthy mice were injected with TCO-BP f

SUBMITTER: Maitz CA 

PROVIDER: S-EPMC10316029 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature