Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.

ABSTRACT: Circadian rhythms are essential to physiological homeostasis, but often disrupted in the intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to treatments which affect circadian regulators. This is increasingly recognized as a contributor to morbidity and mortality across a variety of medical conditions including critical illness. Maintenance of circadian rhythms is particularly relevant to critically ill patients, who are restricted not only to the ICU environment but often bed bound. Circadian rhythms have been evaluated in several ICU studies, but effective therapies to maintain, restore, or amplify circadian rhythms have not been fully established yet. Circadian entrainment and circadian amplitude enhancement are integral to patients' overall health and well

SUBMITTER: Prin M 

PROVIDER: S-EPMC10316098 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature