Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.

ABSTRACT:

Background

Focal segmental glomerulosclerosis (FSGS) is frequently associated with heavy proteinuria and progressive renal failure requiring dialysis or kidney transplantation. However, primary FSGS also has a ~40% risk of recurrence of disease in the transplanted kidney (rFSGS). Multiple circulating factors have been identified to contribute to the pathogenesis of primary and rFSGS including soluble urokinase-type plasminogen activator receptor (suPAR) and patient-derived CD40 autoantibody (CD40autoAb). However, the downstream effector pathways specific to individual factors require further study. The tumor necrosis factor, TNF pathway activation by one or more circulating factors present in the sera of patients with FSGS has been supported by multiple studies.

Methods

A hu

SUBMITTER: Rashmi P 

PROVIDER: S-EPMC10316099 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature