Translocations and Gene Fusions in Sinonasal Malignancies.

ABSTRACT:

Purpose of review

During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed.

Recent findings

Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate tha

SUBMITTER: Larkin R 

PROVIDER: S-EPMC10316133 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature