Metabolic disorders induced by PNPLA3 and TM6SF2 gene variants affect chronic kidney disease in patients infected with non-genotype 3 hepatitis C virus.

ABSTRACT:

Background

Patients with chronic hepatitis C virus (HCV) infections differ in their risk for metabolic disorders and chronic kidney disease (CKD). The aim of this study was to investigate the effect of metabolic disorders induced by genetic factors on CKD in HCV-infected patients.

Methods

Patients with chronic non-genotype 3 HCV infection with or without CKD were examined. PNPLA3 and TM6SF2 variants were determined using high-throughput sequencing. The relationships of variants and different combinations with metabolic disorders were analyzed in CKD patients. Univariate and multivariate analyses were used to identify factors associated with CKD.

Results

There were 1022 patients with chronic HCV infection, 226 with CKD and 796 without CKD. The CKD group had more severe

SUBMITTER: Liu J 

PROVIDER: S-EPMC10316563 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature