Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression.

ABSTRACT:

Background

Circular RNAs (circRNAs), which are involved in various human malignancies, have emerged as promising biomarkers. The present study aimed to investigate unique expression profiles of circRNAs in hepatocellular carcinoma (HCC) and identify novel biomarkers associated with HCC development and progression.

Methods

CircRNA expression profiles of HCC tissues were jointly analyzed to identify differentially expressed circRNAs. Overexpression plasmid and siRNA targeting candidate circRNAs were used in functional assays in vitro. CircRNA-miRNA interactions were predicted using miRNAs expressed in the miRNA-seq dataset GSE76903. To further screen downstream genes targeted by the miRNAs, survival analysis and qRT-PCR were conducted to evaluate their prognostic role in HCC a

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10316602 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature