Differential expression of the circadian clock network correlates with tumour progression in gliomas.

ABSTRACT:

Background

Gliomas are tumours arising mostly from astrocytic or oligodendrocytic precursor cells. These tumours are classified according to the updated WHO classification from 2021 in 4 grades depending on molecular and histopathological criteria. Despite novel multimodal therapeutic approaches, the vast majority of gliomas (WHO grade III and IV) are not curable. The circadian clock is an important regulator of numerous cellular processes and its dysregulation had been found during the progression of many cancers, including gliomas.

Results

In this study, we explore expression patterns of clock-controlled genes in low-grade glioma (LGG) and glioblastoma multiforme (GBM) and show that a set of 45 clock-controlled genes can be used to distinguish GBM from normal tissue. Subse

SUBMITTER: Petkovic M 

PROVIDER: S-EPMC10316603 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature