TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα.

ABSTRACT:

Background

Human aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletely understood. It is known, however, that macrophages play a driving role in establishing inflammaging by promoting pro-inflammatory rather than anti-inflammatory responses. Numerous genetic and environmental risk factors have been implicated with inflammaging, most of which are directly linked to pro-inflammatory mediators IL-6, IL1Ra, and TNFα. Genes involved in the signaling and production of those molecules have also been highlighted as essential contributors. TAOK3 is a serine/threonine kinase of the STE-20 kinase family that has been associated with an increased risk of developing auto-immune conditions in several genome-wide association studies

SUBMITTER: Poirier A 

PROVIDER: S-EPMC10316641 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature